San Diego Nightlife: When it comes to setting the standard for extravagant party nights and nighttime entertainment, nothing beats San Diego nightlife and the hottest parties on California's West Coast. A laid-back beach town like San Diego boasts countless world-class choices, including nightclubs with exhilarating DJs, live international entertainment, comedy, arcade games, and cocktails that are works of art. Party 'til you drop with this guide to the best nightclubs and dance clubs in San Diego.